{"id":4305,"date":"2025-07-29T16:49:09","date_gmt":"2025-07-29T14:49:09","guid":{"rendered":"https:\/\/mikrobiomik.net\/first-patient-for-phase-iii-trial-in-decompensated-liver-cirrhosis\/"},"modified":"2026-02-03T20:03:36","modified_gmt":"2026-02-03T19:03:36","slug":"first-patient-for-phase-iii-trial-in-decompensated-liver-cirrhosis","status":"publish","type":"post","link":"https:\/\/mikrobiomik.net\/en\/first-patient-for-phase-iii-trial-in-decompensated-liver-cirrhosis\/","title":{"rendered":"First patient for phase III trial in decompensated liver cirrhosis"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”” text_direction=”default”]\n

A new milestone achieved: the first patient is recruited for the phase III trial in decompensated liver cirrhosis.<\/strong><\/h2>\n

\"decompensated<\/p>\n

We have begun recruiting patients for LiverGut,<\/strong> a phase III multicentre clinical trial authorised by the AEMPS, which will evaluate the therapeutic potential of MBK-01<\/strong> to slow the progression of decompensated liver cirrhosis<\/strong>.<\/p>\n

The study is led by Hospital Cl\u00ednic from Barcelona<\/strong>, under the coordination of Dr Pere Gin\u00e8s<\/strong>, an international leader in hepatology. A total of 190 adult patients<\/strong> with decompensated cirrhosis, recruited from eight hospitals in Spain<\/strong>, will participate. The main objective is to measure the time to the first event of decompensation,<\/strong> such as ascites, infections, gastrointestinal bleeding or hepatic encephalopathy.<\/p>\n

In recent years, research has revealed that intestinal dysbiosis <\/strong>and mucosal barrier disruption play a key role in the progression of cirrhosis. Bacterial translocation<\/strong> from the intestine to the liver exacerbates systemic inflammation and complications of this disease.<\/p>\n

Decompensated cirrhosis is one of the leading causes of hospitalisation and mortality in hepatology. Currently, there is no treatment that can slow its progression<\/strong>. LiverGut is the first clinical trial in Europe to evaluate a microbiota-based therapy for this indication<\/strong> and could lay the foundations for a new therapeutic strategy in advanced hepatology.<\/p>\n

With LiverGut, we are positioning microbiota modulation as a central axis in the treatment of complex chronic diseases,<\/strong> with safe, effective and sustainable solutions.[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

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column_shadow=”none”…<\/p>\n","protected":false},"author":1,"featured_media":4303,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46,96,70],"tags":[],"class_list":{"0":"post-4305","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-clinical-trials","8":"category-mbk-01","9":"category-news-en"},"yoast_head":"\nFirst patient for phase III trial in decompensated liver cirrhosis<\/title>\n<meta name=\"description\" content=\"A new milestone achieved: the first patient is recruited for the phase III trial in decompensated liver cirrhosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mikrobiomik.net\/en\/first-patient-for-phase-iii-trial-in-decompensated-liver-cirrhosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First patient for phase III trial in decompensated liver cirrhosis\" \/>\n<meta property=\"og:description\" content=\"A new milestone achieved: the first patient is recruited for the phase III trial in decompensated liver cirrhosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mikrobiomik.net\/en\/first-patient-for-phase-iii-trial-in-decompensated-liver-cirrhosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mikrobiomik\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-29T14:49:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-03T19:03:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mikrobiomik.net\/wp-content\/uploads\/ensayo-en-cirrosis-hepatica-descompensada.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" 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