{"id":3439,"date":"2024-05-23T17:34:21","date_gmt":"2024-05-23T15:34:21","guid":{"rendered":"https:\/\/mikrobiomik.net\/clostridium-difficile-clinical-trial\/"},"modified":"2024-05-27T14:56:18","modified_gmt":"2024-05-27T12:56:18","slug":"clostridium-difficile-clinical-trial","status":"publish","type":"page","link":"https:\/\/mikrobiomik.net\/en\/clostridium-difficile-clinical-trial\/","title":{"rendered":"Clostridium Difficile Clinical Trial"},"content":{"rendered":"[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;10px&#8221; equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; bg_image=&#8221;3291&#8243; bg_position=&#8221;left center&#8221; background_image_loading=&#8221;default&#8221; bg_repeat=&#8221;no-repeat&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; 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column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;24px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.6vw&#8221;]\n<h2>RESULTS<\/h2>\n[\/nectar_responsive_text][nectar_responsive_text font_size_min=&#8221;28&#8243; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;2.4vw&#8221; font_size_phone=&#8221;1.4vw&#8221;]\n<h1>ICD-01 clinical trial<\/h1>\n[\/nectar_responsive_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color=&#8221;#ffffff&#8221; background_color_opacity=&#8221;0.3&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_row_inner column_margin=&#8221;20px&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/6&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][image_with_animation image_url=&#8221;3289&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][\/vc_column_inner][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;5\/6&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<em>Clostridium Difficile<\/em> (CD) is the main pathogen responsible for antibiotic-associated diarrhea in developed countries and the most common cause of infectious diarrhea inside hospitals. Fidaxomicin is an approved antibiotic against <em>Clostridium Difficile<\/em> infections (CDI), while Fecal Microbiota Transplantation (FMT) has emerged as an effective and safe treatment for recurrent CDI. <strong>The aim was to assess the efficacy and safety<\/strong> of the experimental product MBK-01 compared to fidaxomicin in CDI cases, 8 weeks after the start of the treatment, evaluating the absence of recurrences.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; bg_color=&#8221;#f2f2f1&#8243; scene_position=&#8221;center&#8221; top_padding=&#8221;4%&#8221; bottom_padding=&#8221;4%&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; gradient_type=&#8221;default&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; constrain_group_1=&#8221;yes&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221;]\n<h2>Abstract<\/h2>\n[\/nectar_responsive_text][\/vc_column][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;2\/3&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]92 patients from 21 sites in Spain were randomly distributed.<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><strong>MBK-01 group: <\/strong>45 patients<\/li>\n<li><strong>Fidaxomicina group: <\/strong>47 patients<\/li>\n<\/ul>\n<p style=\"padding-left: 30px;\">*23 and 25 patients completing the study, respectively .<\/p>\n<p>In the <strong>overall population,<\/strong><strong>89.19% of the MBK-01-treated patients had no recurrence <\/strong>of CDI-associated diarrhea, while for fidaxomicin it was 77.50%.<\/p>\n<p>MBK-01 proved non-inferiority than fidaxomicin in primary CDI cases and within patients with <strong> no previous antibiotic treatment <\/strong>(p&lt;0.01), as MBK-01 was 100% effective versus 80% for fidaxomicin in this subgroup.<\/p>\n<p>For <strong>recurrent CDI cases<\/strong> there was a significant difference in proportions of 0.4279 (p=0.014), thus demonstrating <strong>superiority of MBK-01 <\/strong>over fidaxomicin. Diarrhea was the only treatment-related Adverse Event for both groups, with MBK-01 showing less events than fidaxomicin (<span style=\"font-weight: 400;\">46,35% vs. 53,65%<\/span>).<\/li>\n<\/ul>\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; top_padding=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; shape_type=&#8221;&#8221; gradient_type=&#8221;default&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;right&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;5\/6&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_row_inner equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;8%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;8%&#8221; left_padding_desktop=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; right_padding_desktop=&#8221;4%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;topline&#8221;][vc_column_inner column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221;]\n<h2>Topline results<\/h2>\n[\/nectar_responsive_text][image_with_animation image_url=&#8221;3129&#8243; image_size=&#8221;full&#8221; animation_type=&#8221;entrance&#8221; animation=&#8221;None&#8221; animation_movement_type=&#8221;transform_y&#8221; hover_animation=&#8221;none&#8221; alignment=&#8221;&#8221; border_radius=&#8221;none&#8221; box_shadow=&#8221;none&#8221; image_loading=&#8221;default&#8221; max_width=&#8221;100%&#8221; max_width_mobile=&#8221;default&#8221;][\/vc_column_inner][vc_column_inner column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;right&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;50&#8243;]<div class=\"nectar-fancy-ul font_size_min_14px\" data-list-icon=\"fa fa-arrow-circle-right\" data-animation=\"false\" data-animation-delay=\"0\" data-color=\"accent-color\" data-spacing=\"25px\" data-alignment=\"left\"> \n<ul>\n<li>MBK-01 is considered non inferior to Fidaxomicin in efficacy and security in the CDI treatment.<\/li>\n<li>MBK-01 is considered non inferior to Fidaxomicin for the primary infection in the CDI treatment (1:1).<\/li>\n<li>MBK-01 is superior to fidaxomicin for the treatment of recurrent CDI (7:1)..<\/li>\n<li>The superiority of MBK-01 over fidaxomicin becomes more pronounced as the number of prior recurrences increases<\/li>\n<li>MBK-01 is 100% effective in the patients without an antibiotic pre-treatment.<\/li>\n<li>The treatment with MBK-01 is 100% safe (no SAEs).<\/li>\n<\/ul>\n <\/div>[\/vc_column_inner][\/vc_row_inner][divider line_type=&#8221;Full Width Line&#8221; line_thickness=&#8221;1&#8243; divider_color=&#8221;extra-color-1&#8243;][vc_row_inner equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;8%&#8221; constrain_group_2=&#8221;yes&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;protocol&#8221;][vc_column_inner column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221;]\n<h2>Protocol<\/h2>\n[\/nectar_responsive_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<strong>Official title <\/strong><\/p>\n<p>A Randomised, Controlled, Open-label Phase III Clinical Trial in Patients With Primary or Recurrent <em>Clostridioides Difficile<\/em> (CD)Infection, to Evaluate the Efficacy and Safety of MBK-01, Capsules of Lyophilised Faecal Microbiota vs Fidaxomicin.<\/p>\n<p><strong>Clinical Trials.gov ID<\/strong> NCT05201079[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221;][\/nectar_responsive_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<strong>Follow up:<\/strong><\/p>\n<p>Participants should return for clinic visits at 72 hours, week 3 and week 8 after the start of the treatment, and receive follow-up phone calls at month 3 and month 6 after the start of the treatment. Stool samples collected from participants for further studies at time 0 and week 8 after the start of the treatment.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][toggles style=&#8221;minimal_shadow&#8221; accordion=&#8221;true&#8221; accordion_starting_functionality=&#8221;closed&#8221; border_radius=&#8221;15px&#8221;][toggle color=&#8221;Accent-Color&#8221; heading_tag=&#8221;h5&#8243; heading_tag_functionality=&#8221;default&#8221; title=&#8221;Inclusion Criteria&#8221;][nectar_responsive_text font_size_min=&#8221;14px&#8221; font_size_max=&#8221;20px&#8221; text_color=&#8221;#000000&#8243; text_direction=&#8221;default&#8221;]\n<ul>\n<li>Patients of both genders, over 18 years.<\/li>\n<li>Patients that undergo an episode of CD infection (either the first episode or subsequent recurrences).<\/li>\n<li>Presence of an episode of diarrhea defined as \u22653 stools\/24 hours, at the beginning of the episode.<\/li>\n<li>Confirmation of the presence of CD toxin A and\/or B in stool, by a direct toxin detection test or by the PCR technique for the detection of toxin\/s producing genes, at the start of the episode that is going to be treated in the clinical trial (the toxin test must be positive within 7 days prior to the enrolment of the patient in the trial).<\/li>\n<\/ul>\n[\/nectar_responsive_text][\/toggle][toggle color=&#8221;Accent-Color&#8221; heading_tag=&#8221;h5&#8243; heading_tag_functionality=&#8221;change_html_tag&#8221; title=&#8221;Exclusion Criteria&#8221;][nectar_responsive_text font_size_min=&#8221;14px&#8221; font_size_max=&#8221;20px&#8221; text_color=&#8221;#000000&#8243; font_line_height=&#8221;1.6&#8243; text_direction=&#8221;default&#8221;]\n<ul>\n<li>Previous fecal microbiota transfer.<\/li>\n<li>Transplanted patients, except those with a solid organ transplant of more than 2 years, with good organ function.<\/li>\n<li>Absolute neutrophil count &lt;500 cells \/\u03bcL at the time of the enrollment in the study.<\/li>\n<li>Pregnancy, breastfeeding, or pregnancy intentions over the course of the study.<\/li>\n<li>Active treatment with bile acid sequestrants (for instance: cholestyramine).<\/li>\n<li>Positive patients for the human immunodeficiency virus (HIV) except those with lymphocytes T CD4 count &gt; 200 cells\/\u03bcL and viral load less than 20 copies.<\/li>\n<li>Swallowing dysfunction or no oral motor coordination.<\/li>\n<li>Patients admitted in an intensive care unit or expected to be admitted in an intensive care unit due to serious illness.<\/li>\n<li>History of significant medical conditions that, in the opinion of the investigator, would not allow an adequate evaluation or follow-up of the patient.<\/li>\n<\/ul>\n[\/nectar_responsive_text][\/toggle][\/toggles][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][divider line_type=&#8221;Full Width Line&#8221; line_thickness=&#8221;1&#8243; divider_color=&#8221;extra-color-1&#8243;][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;8%&#8221; bottom_padding=&#8221;2%&#8221; left_padding_desktop=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; right_padding_desktop=&#8221;4%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;sites&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;no-extra-padding&#8221; column_padding_position=&#8221;left-right&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221;]\n<h2 style=\"text-align: left;\">Sites<\/h2>\n[\/nectar_responsive_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; bottom_padding=&#8221;8%&#8221; left_padding_desktop=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; right_padding_desktop=&#8221;4%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;hospitales&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;no-extra-padding&#8221; column_padding_position=&#8221;left-right&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/2&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221; offset=&#8221;vc_hidden-xs&#8221;][nectar_image_with_hotspots image=&#8221;3238&#8243; preview=&#8221;https:\/\/mikrobiomik.net\/wp-content\/uploads\/hospitales-icd-1-e1716307467469.png&#8221; color_1=&#8221;Accent-Color&#8221; hotspot_icon=&#8221;numerical&#8221; tooltip=&#8221;click&#8221; tooltip_shadow=&#8221;none&#8221;][nectar_hotspot left=&#8221;38.47770467836257%&#8221; top=&#8221;42.33214368850167%&#8221; position=&#8221;top&#8221;]Madrid[\/nectar_hotspot][nectar_hotspot left=&#8221;79.8493%&#8221; top=&#8221;25.76%&#8221; position=&#8221;top&#8221;]Barcelona[\/nectar_hotspot][nectar_hotspot left=&#8221;29.3785%&#8221; top=&#8221;71.4137%&#8221; position=&#8221;top&#8221;]C\u00f3rdoba[\/nectar_hotspot][nectar_hotspot left=&#8221;89.14%&#8221; top=&#8221;51.455%&#8221; position=&#8221;top&#8221;]Mallorca[\/nectar_hotspot][nectar_hotspot left=&#8221;35.656%&#8221; top=&#8221;7.52996%&#8221; position=&#8221;top&#8221;]Santander[\/nectar_hotspot][nectar_hotspot left=&#8221;44.0543773207655%&#8221; top=&#8221;7.043492313654936%&#8221; position=&#8221;top&#8221;]Bilbao[\/nectar_hotspot][nectar_hotspot left=&#8221;46.83036989431591%&#8221; top=&#8221;13.279172929535044%&#8221; position=&#8221;top&#8221;]Vitoria-Gasteiz[\/nectar_hotspot][nectar_hotspot left=&#8221;51.12200085689803%&#8221; top=&#8221;7.735104265138504%&#8221; position=&#8221;top&#8221;]Donostia-San Sebasti\u00e1n[\/nectar_hotspot][nectar_hotspot left=&#8221;57.376%&#8221; top=&#8221;28.2745%&#8221; position=&#8221;top&#8221;]Zaragoza[\/nectar_hotspot][nectar_hotspot left=&#8221;46.634890031419594%&#8221; top=&#8221;20.215403938921124%&#8221; position=&#8221;top&#8221;]Logro\u00f1o[\/nectar_hotspot][nectar_hotspot left=&#8221;61.5191%&#8221; top=&#8221;55.2267%&#8221; position=&#8221;top&#8221;]Valencia[\/nectar_hotspot][nectar_hotspot left=&#8221;62.1469%&#8221; top=&#8221;66.8562%&#8221; position=&#8221;top&#8221;]Alicante[\/nectar_hotspot][nectar_hotspot left=&#8221;86.2524%&#8221; top=&#8221;20.3381%&#8221; position=&#8221;top&#8221;]Girona[\/nectar_hotspot][nectar_hotspot left=&#8221;23.1011%&#8221; top=&#8221;81.0002%&#8221; position=&#8221;top&#8221;]Sevilla[\/nectar_hotspot][nectar_hotspot left=&#8221;31.0097%&#8221; top=&#8221;87.7579%&#8221; position=&#8221;top&#8221;]M\u00e1laga[\/nectar_hotspot][nectar_hotspot left=&#8221;22.9755%&#8221; top=&#8221;14.602%&#8221; position=&#8221;top&#8221;]Le\u00f3n[\/nectar_hotspot][\/nectar_image_with_hotspots][\/vc_column_inner][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<strong><span style=\"color: #ea5195;\">1.MADRID<\/span><\/strong><br \/>\nHospital Ram\u00f3n y Cajal<br \/>\nHU 12 de Octubre<br \/>\nHU Puerta de Hierro<br \/>\nHU Gregorio Mara\u00f1\u00f3n<br \/>\nHU La Paz<br \/>\nHU Quir\u00f3n Salud Madrid<br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nH Central de La Defensa G\u00f3mez Ulla<\/p>\n<p><strong><span style=\"color: #ea5195;\">2. BARCELONA<\/span><\/strong><br \/>\nHU de Bellvitge<br \/>\nHospital Cl\u00ednic<br \/>\nH Quir\u00f3n Salud Barcelona<\/p>\n<p><strong><span style=\"color: #ea5195;\">3. C\u00d3RDOBA<\/span><\/strong><br \/>\nHU Reina Sof\u00eda<\/p>\n<p><strong><span style=\"color: #ea5195;\">4. MALLORCA<\/span><\/strong><br \/>\nHU Son Espases<\/p>\n<p><strong><span style=\"color: #ea5195;\">5. SANTANDER<\/span><\/strong><br \/>\nHU Marqu\u00e9s de Valdecilla<\/p>\n<p><strong><span style=\"color: #ea5195;\">6. BILBAO<\/span><\/strong><br \/>\nHU de Cruces<br \/>\nHU de Basurto<br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nH de G\u00f3rliz (Bizkaia)<br \/>\nH de Urduliz (Bizkaia)<br \/>\nH San Juan de Dios (Bizkaia)<\/p>\n<p><strong><span style=\"color: #ea5195;\">7. ARABA-ALAVA<\/span><\/strong><br \/>\nHU de Araba[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<strong><span style=\"color: #ea5195;\">8. DONOSTIA-SAN SEBASTI\u00c1N<\/span><\/strong><br \/>\nHU de Donostia<\/p>\n<p><strong><span style=\"color: #ea5195;\">9. ZARAGOZA<\/span><\/strong><br \/>\nHU Lozano Blesa<br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nHU Miguel Servet<\/p>\n<p><strong><span style=\"color: #ea5195;\">10. LOGRO\u00d1O<\/span><\/strong><br \/>\nHospital San Pedro<\/p>\n<p><strong><span style=\"color: #ea5195;\">11. VALENCIA<\/span><\/strong><br \/>\nHU y Polit\u00e9cnico La Fe<\/p>\n<p><strong><span style=\"color: #ea5195;\">12. ALICANTE<\/span><\/strong><br \/>\nHU de Alicante<\/p>\n<p><strong><span style=\"color: #ea5195;\">13. GIRONA<\/span><\/strong><br \/>\nHU de Girona Doctor Josep Trueta<\/p>\n<p><strong><span style=\"color: #ea5195;\">14. SEVILLA<\/span><\/strong><br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nHU Virgen del Roc\u00edo<\/p>\n<p><strong><span style=\"color: #ea5195;\">15. M\u00c1LAGA<\/span><\/strong><br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nHU de M\u00e1laga<\/p>\n<p><strong><span style=\"color: #ea5195;\">16. LE\u00d3N<\/span><\/strong><br \/>\n<strong>COMPASIVE USE<\/strong><br \/>\nHU de Le\u00f3n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][divider line_type=&#8221;Full Width Line&#8221; line_thickness=&#8221;1&#8243; divider_color=&#8221;extra-color-1&#8243;][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;8%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;8%&#8221; left_padding_desktop=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; right_padding_desktop=&#8221;4%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;cdifficile&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221; font_line_height=&#8221;1.2&#8243;]\n<h2><em>Clostridium Difficile<\/em> &#8211; CDI<\/h2>\n[\/nectar_responsive_text][\/vc_column_inner][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;3\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]CDI arises when the colon becomes colonized by <em>Clostridium Difficile,<\/em> bacteria, resulting in an imbalance of gut microorganisms. that is <strong>dysbiosis<\/strong>. This imbalance is primarily triggered by antibiotic use. CDI leads to a range of symptoms, ranging from watery diarrhea to life-threatening colitis.[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<span style=\"color: #ea5195;\"><strong>Clinical manifestation<\/strong><\/span>[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<ul>\n<li><strong>Antibiotic exposure:<\/strong>nearly every antibiotic has been associated with the development of CDI, including those used for treatment of CDI: Metronidazole and Vancomycin. High-risk CDI associated antibiotics are broad spectrum penicillin, cephalosporins, clindamycin, and fluoroquinolones.<\/li>\n<li><strong>Age &gt; 65 years:<\/strong> advancing age increases the risk of infection. Nonetheless a significant number of cases occur in a younger population.<\/li>\n<li><strong>Hospitalization or nursing home stay<\/strong>: the incidence of <em>Clostridium Difficile,<\/em> colonization increases with the duration of the hospitalization. Recent studies suggest that the incidence of community-acquired CDI is growing.<\/li>\n<li><strong>Protective barrier: <\/strong>normal intestinal microflora. When the balance of gut microorganisms is disrupted, <em>Clostridium Difficile<\/em> bacteria starts to dominate and colonize the large intestine which indicates the first step of infection.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<span style=\"color: #ea5195;\"><strong>Risk factors<\/strong><\/span>[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<ul>\n<li><strong>Colonization of the distal segment<\/strong> despite CDI can affect any part of the colon, the distal segment is the zone most commonly affected. Treatment should not be initiated solely based on a positive laboratory test for <em>Clostridium Difficile<\/em><em>, <\/em>without any accompanying symptoms.<\/li>\n<li><strong>Watery diarrhea:<\/strong> occurs in most cases during, or directly after, antimicrobial therapy, although CDI onset might be also a couple of weeks afterwards.<\/li>\n<li><strong>Other clinical features: <\/strong>abdominal pain, fever, nausea, vomiting, weakness, and loss of appetite. Fecal blood test is often positive, although active bleeding is rarely present.<\/li>\n<li><strong>Toxins<\/strong>: <em>Clostridium Difficile<\/em> produces two types of toxins, enterotoxin A and cytotoxin B. These toxins are transported to the cell cytoplasm disestablishing the cell cytoskeleton and causing inflammatory process and tissue damage.<\/li>\n<\/ul>\n[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]<span style=\"color: #ea5195;\"><strong>Guidelines<\/strong><\/span>[\/vc_column_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]More information on:<\/p>\n<p><a href=\"https:\/\/www.idsociety.org\/practice-guideline\/clostridioides-difficile-2021-focused-update\/\" target=\"_blank\" rel=\"noopener\">Infectious Diseases Society of America<\/a><\/p>\n<p><a href=\"https:\/\/www.clinicalmicrobiologyandinfection.com\/article\/S1198-743X(21)00568-1\/fulltext\" target=\"_blank\" rel=\"noopener\">Clinical Microbiology and Infectious Diseases<\/a><\/p>\n<p><a href=\"https:\/\/journals.lww.com\/ajg\/Fulltext\/2021\/06000\/ACG_Clinical_Guidelines__Prevention,_Diagnosis,.12.aspx#xd_co_f=NDMzZjA4ZmQtZGE3YS00MTYyLThhYzQtMTcxYzNhNDE0ZDky~\" target=\"_blank\" rel=\"noopener\">The American Journal of Gastroenterology<\/a><\/p>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/mtg71\" target=\"_blank\" rel=\"noopener\">NICE<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;4%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;4%&#8221; left_padding_desktop=&#8221;4%&#8221; constrain_group_2=&#8221;yes&#8221; right_padding_desktop=&#8221;4%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;webinar-results&#8221; css=&#8221;.vc_custom_1716806405487{background-color: #f2f2f1 !important;border-radius: 20px !important;}&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;1.8vw&#8221; font_line_height=&#8221;1.2&#8243;]\n<h2>Webinar, presentation of final results<\/h2>\n[\/nectar_responsive_text][\/vc_column_inner][vc_column_inner column_padding=&#8221;padding-4-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;3\/4&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<p style=\"text-align: left;\">In April we presented the results of the clinical trial, during a streaming where outstanding professionals who where part of the study submitted the results from their different perspectives<\/p>\n[\/vc_column_text][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;15&#8243;][nectar_responsive_text font_size_min=&#8221;14px&#8221; text_color=&#8221;#ea5195&#8243; text_direction=&#8221;default&#8221;]Presentation of the final results: Juan Barrero de la Rubia \u2013 Project Controller of SERMES CRO[\/nectar_responsive_text][nectar_video_lightbox link_style=&#8221;play_button_2&#8243; nectar_play_button_color=&#8221;Default-Accent-Color&#8221; image_url=&#8221;3033&#8243; hover_effect=&#8221;zoom_button&#8221; box_shadow=&#8221;none&#8221; border_radius=&#8221;20px&#8221; play_button_size=&#8221;default&#8221; video_url=&#8221;https:\/\/youtu.be\/3lqypKMjFgo&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;15&#8243;][nectar_responsive_text font_size_min=&#8221;14px&#8221; text_color=&#8221;#ea5195&#8243; text_direction=&#8221;default&#8221;]Discussion\/Analysis of final results: Dr. Javier Cobo Reinoso, Trial Coordinator, Ram\u00f3n y Cajal University Hospital.[\/nectar_responsive_text][nectar_video_lightbox link_style=&#8221;play_button_2&#8243; nectar_play_button_color=&#8221;Default-Accent-Color&#8221; image_url=&#8221;3030&#8243; hover_effect=&#8221;zoom_button&#8221; box_shadow=&#8221;none&#8221; border_radius=&#8221;20px&#8221; play_button_size=&#8221;default&#8221; video_url=&#8221;https:\/\/youtu.be\/XNxaeYX2Kuc&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;15&#8243;][nectar_responsive_text font_size_min=&#8221;14px&#8221; text_color=&#8221;#ea5195&#8243; text_direction=&#8221;default&#8221;]About compassionate use case &#8211; Dra. Mar\u00eda Varela Cerdeira, Hospital Universitario La Paz.[\/nectar_responsive_text][nectar_video_lightbox link_style=&#8221;play_button_2&#8243; nectar_play_button_color=&#8221;Default-Accent-Color&#8221; image_url=&#8221;3032&#8243; hover_effect=&#8221;zoom_button&#8221; box_shadow=&#8221;none&#8221; border_radius=&#8221;20px&#8221; play_button_size=&#8221;default&#8221; video_url=&#8221;https:\/\/youtu.be\/nrM5_CDVOBw&#8221;][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; top_padding=&#8221;8%&#8221; constrain_group_1=&#8221;yes&#8221; bottom_padding=&#8221;8%&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221; el_id=&#8221;contact&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; centered_text=&#8221;true&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][nectar_responsive_text font_size_min=&#8221;26px&#8221; text_color=&#8221;#067078&#8243; text_direction=&#8221;default&#8221; font_size_desktop=&#8221;2.8vw&#8221;]\n<h2>Contact us<\/h2>\n[\/nectar_responsive_text][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<h5>For more information or more details about the clinical trial, write to us at:<\/h5>\n<h4><span style=\"color: #ea5195;\"><a style=\"color: #ea5195;\" href=\"mailto:ensayosclinicos@mikrobiomik.net\" target=\"_blank\" rel=\"noopener\">ensayosclinicos@mikrobiomik.net<\/a><\/span><\/h4>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column column_padding=&#8221;padding-2-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;left&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; sticky_content=&#8221;true&#8221; sticky_content_functionality=&#8221;js&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/6&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;advanced&#8221; border_left_desktop=&#8221;1px&#8221; column_border_color=&#8221;#ea5195&#8243; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221; offset=&#8221;vc_hidden-xs&#8221;][vc_widget_sidebar enable_sticky=&#8221;true&#8221; sidebar_id=&#8221;nectar-extra-sidebar&#8221; el_id=&#8221;menuensayo&#8221;][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;full_width_background&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;10px&#8221; equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; bg_image=&#8221;3291&#8243; bg_position=&#8221;left center&#8221; background_image_loading=&#8221;default&#8221; bg_repeat=&#8221;no-repeat&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; 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